"Blood coagulation, intrinsic pathway"

Across TCGA cell cohorts, RNA activity of the "Blood coagulation, intrinsic pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2L3, PPEF1, and SIX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2L3 grouped by "Blood coagulation, intrinsic pathway"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OR2L3 →	+0.198	+0.325	.005	.009	3	6
PANCREAS	PPEF1 →	-0.265	-0.269	.001	.005	3	5
URINARY_TRACT	SIX2 →	+0.286	+0.282	<.001	.001	3	5
OESOPHAGUS	ATF7IP2 →	+0.182	+0.379	.002	<.001	3	5
KIDNEY	PUS7L →	+0.173	+0.402	.003	.001	3	5
KIDNEY	SCGB3A1 →	-0.210	-0.342	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2L3 by "Blood coagulation, intrinsic pathway" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →