"Blood coagulation, intrinsic pathway"

Across TCGA cell cohorts, RNA activity of the "Blood coagulation, intrinsic pathway" pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FY012, ZL109, and VNLG/124, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FY012 grouped by "Blood coagulation, intrinsic pathway"-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FY012 →	+0.445	+0.227	.014	.044	2	1
CNS	ZL109 →	+0.390	+0.227	.016	.044	2	1
CNS	VNLG/124 →	-0.325	-0.200	.011	.029	2	1
CNS	SNX-2112 →	+0.960	+0.227	.045	.044	2	1
CNS	TWS119 →	+0.659	+0.227	.017	.044	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest associations by consensus.

FY012 by "Blood coagulation, intrinsic pathway" activity — CNS

Explore this box plot interactively →