Body fluid secretion

Across TCGA patient cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2B, RFC1_T506, and STMN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body fluid secretion activity versus TOP2B in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP2B →	-0.412	-0.042	<.001	<.001	3	6
LSCC	RFC1_T506 →	-1.028	-0.062	<.001	<.001	3	5
LSCC	STMN1 →	-0.499	-0.033	.001	<.001	3	5
GBM	SNTB2_S222 →	+0.758	+0.045	<.001	<.001	3	5
OV	SIRT6_S303 →	-1.637	-0.040	<.001	.001	3	5
OV	ZNF318_S709 →	-0.764	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007589 vs TOP2B — GBM

Explore this scatter interactively →