Body fluid secretion

Across TCGA patient cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GNTL1P1, DENR, and NTRK3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body fluid secretion activity versus B3GNTL1P1 in PDAC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	B3GNTL1P1 →	-0.505	-0.382	.003	.001	3	3
CCRCC	DENR →	+0.166	+0.160	.008	.001	3	3
CCRCC	NTRK3 →	-0.387	-0.136	.003	.008	3	3
UCEC	DDX55 →	+0.556	+0.138	.008	.006	3	3
COAD	BTG4 →	+0.045	+0.129	.004	.002	3	3
LSCC	KCNA5 →	-0.332	-0.155	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007589 vs B3GNTL1P1 — PDAC

Explore this scatter interactively →