Body fluid secretion

Across TCGA cell cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, MAGEB10, and WNK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDN1 grouped by Body fluid secretion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EDN1 →	-0.161	-0.165	.008	<.001	2	6
STOMACH	MAGEB10 →	-0.131	-0.263	<.001	<.001	3	4
LARGE_INTESTINE	WNK1 →	-0.250	-0.132	.007	.009	1	6
STOMACH	TMEM259 →	+0.175	+0.267	.001	.002	3	4
BREAST	CCND1 →	-0.693	-0.242	<.001	<.001	3	4
BLOOD_Myeloma	IL6R →	-0.267	-0.166	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDN1 by Body fluid secretion activity — LARGE_INTESTINE

Explore this box plot interactively →