Body fluid secretion

Across TCGA cell cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX5, AFF1, and VAV2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDX5 grouped by Body fluid secretion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRDX5 →	+0.141	+0.118	.005	.003	3	5
SOFT_TISSUE	AFF1 →	+0.207	+0.123	.001	.001	3	5
STOMACH	VAV2 →	-0.131	-0.128	.002	.004	3	5
CNS	FNBP1 →	-0.281	-0.149	<.001	.001	3	5
CNS	NRCAM →	-0.184	-0.102	.001	.005	3	4
LUNG_NSCLC_LUAD	EPB41 →	+0.135	+0.117	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDX5 by Body fluid secretion activity — SOFT_TISSUE

Explore this box plot interactively →