Body fluid secretion

Across TCGA cell cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL32, HMBS, and IFT57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Body fluid secretion activity versus IL32 in BLOOD_Lymphoma (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL32 →	-4.826	-0.299	<.001	<.001	3	5
PANCREAS	HMBS →	+0.585	+0.222	.001	<.001	3	5
BLOOD_Lymphoma	IFT57 →	+1.306	+0.345	.002	<.001	3	5
PANCREAS	SIGMAR1 →	+0.917	+0.216	.005	<.001	3	4
PANCREAS	ATP6V1C1 →	+0.633	+0.135	.004	.004	3	4
SOFT_TISSUE	MOSPD1 →	-2.514	-0.388	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007589 vs IL32 — BLOOD_Lymphoma

Explore this scatter interactively →