Excretion

Across TCGA patient cohorts, RNA activity of the Excretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SELENBP1, PEA15_S90, and SPTAN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Excretion activity versus SELENBP1 in BRCA (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SELENBP1 →	+0.573	+0.047	.001	.001	3	6
LSCC	PEA15_S90 →	+0.351	+0.039	<.001	<.001	3	6
CCRCC	SPTAN1 →	+0.239	+0.100	<.001	<.001	3	5
COAD	GPD1L →	+0.323	+0.058	.001	.001	3	5
CCRCC	PLVAP →	+0.521	+0.059	<.001	<.001	3	5
OV	DDAH1 →	+0.546	+0.031	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007588 vs SELENBP1 — BRCA

Explore this scatter interactively →