Excretion

Across TCGA patient cohorts, RNA activity of the Excretion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTBN1_T2187, TP53INP1_S156, and CAMSAP2_S522, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Excretion activity versus SPTBN1_T2187 in HNSC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPTBN1_T2187 →	-1.054	-0.738	<.001	<.001	3	3
COAD	TP53INP1_S156 →	+0.578	+0.338	<.001	<.001	3	3
UCEC	CAMSAP2_S522 →	+0.681	+0.288	.001	<.001	3	3
BRCA	SENP7_S444 →	+0.439	+0.598	<.001	<.001	3	3
BRCA	MLLT6 →	+0.564	+0.519	.001	.002	2	4
BRCA	MLLT6_S218 →	+1.073	+0.580	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007588 vs SPTBN1_T2187 — HNSC

Explore this scatter interactively →