Respiratory gaseous exchange by respiratory system

Across TCGA patient cohorts, RNA activity of the Respiratory gaseous exchange by respiratory system pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIG2, MELTF, and CENPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory gaseous exchange by respiratory system activity versus VSIG2 in CCRCC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VSIG2 →	+0.805	+0.098	<.001	<.001	3	5
CCRCC	MELTF →	-1.175	-0.116	<.001	<.001	3	5
LSCC	CENPA →	-0.623	-0.534	<.001	.006	3	5
CCRCC	EMCN →	+0.967	+0.068	<.001	<.001	3	5
LSCC	C6 →	+0.677	+0.608	<.001	.009	3	5
HNSC	SELP →	+1.167	+0.434	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007585 vs VSIG2 — CCRCC

Explore this scatter interactively →