Respiratory gaseous exchange by respiratory system

Across TCGA cell cohorts, RNA activity of the Respiratory gaseous exchange by respiratory system pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS3, PPP1R9B, and SUCLG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS3 grouped by Respiratory gaseous exchange by respiratory system-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RGS3 →	-2.131	-0.874	.008	.004	3	4
OVARY	PPP1R9B →	-0.813	-0.989	.001	.005	3	4
OVARY	SUCLG2 →	-0.919	-1.256	.001	<.001	3	4
OESOPHAGUS	DUSP18 →	-0.831	-1.381	<.001	<.001	3	4
BONE	H2AW →	+2.017	+1.704	.007	<.001	3	4
URINARY_TRACT	CEP250 →	-1.089	-1.612	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS3 by Respiratory gaseous exchange by respiratory system activity — SOFT_TISSUE

Explore this box plot interactively →