Respiratory gaseous exchange by respiratory system

Across TCGA cell cohorts, RNA activity of the Respiratory gaseous exchange by respiratory system pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPO4, HECTD1, and DDX27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory gaseous exchange by respiratory system activity versus IPO4 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IPO4 →	+1.052	+0.153	.004	.002	3	4
STOMACH	HECTD1 →	+0.710	+0.143	.003	<.001	3	4
OESOPHAGUS	DDX27 →	-0.838	-0.139	<.001	.001	3	3
OESOPHAGUS	TBRG4 →	-0.700	-0.140	.003	.003	3	3
KIDNEY	DPM2 →	+0.803	+0.197	<.001	<.001	3	3
KIDNEY	UBAP2 →	+1.381	+0.201	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007585 vs IPO4 — BLOOD_Lymphoma

Explore this scatter interactively →