Parturition

Across TCGA patient cohorts, RNA activity of the Parturition pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS20, RN7SL210P, and KLF18, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parturition activity versus ADAMTS20 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS20 →	-1.443	-0.588	<.001	.002	3	3
GBM	RN7SL210P →	+0.450	+0.713	.008	.005	3	3
PDAC	KLF18 →	+0.023	+0.476	.004	.005	3	3
COAD	ADSS1 →	+0.359	+0.526	.002	.001	3	3
HNSC	RPS6KA2 →	+0.586	+0.537	.001	.006	3	3
BRCA	GCAT →	-0.460	-0.370	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007567 vs ADAMTS20 — LSCC

Explore this scatter interactively →