Parturition

Across TCGA cell cohorts, RNA activity of the Parturition pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFF, MMP2, and FSTL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAFF grouped by Parturition-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAFF →	-0.356	-1.244	.002	<.001	3	6
CNS	MMP2 →	-0.257	-1.239	<.001	<.001	3	6
SOFT_TISSUE	FSTL4 →	-0.412	-1.932	<.001	<.001	3	5
BLOOD_Leukemia	TAAR8 →	-0.196	-1.178	<.001	<.001	3	4
BLOOD_Leukemia	PRKRA →	-0.191	-1.115	.005	.005	3	4
CNS	HPGD →	-0.242	-1.044	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAFF by Parturition activity — BLOOD_Leukemia

Explore this box plot interactively →