Parturition

Across TCGA cell cohorts, RNA activity of the Parturition pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDH, DCTN4, and SLC7A11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAPDH grouped by Parturition-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GAPDH →	+1.027	+1.577	<.001	<.001	3	3
BLOOD_Leukemia	DCTN4 →	+0.897	+1.472	.001	<.001	3	3
LIVER	SLC7A11 →	+1.775	+0.955	.009	.005	3	3
BLOOD_Leukemia	ATG7 →	+1.054	+1.043	<.001	<.001	3	3
STOMACH	BPHL →	-1.001	-0.245	<.001	.001	3	3
LARGE_INTESTINE	OAS3 →	+1.452	+0.470	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAPDH by Parturition activity — LIVER

Explore this box plot interactively →