Parturition

Across TCGA cell cohorts, RNA activity of the Parturition pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX4I1, ABCB6, and PHTF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX4I1 grouped by Parturition-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX4I1 →	-0.267	-1.158	<.001	<.001	3	4
BONE	ABCB6 →	-0.120	-1.641	.008	.002	3	3
BONE	PHTF2 →	-0.188	-1.354	.001	.007	3	3
BLOOD_Leukemia	NFATC4 →	+0.162	+1.201	.001	<.001	3	3
BLOOD_Leukemia	CD28 →	-0.213	-1.154	.002	.002	3	3
BLOOD_Leukemia	TXNIP →	+0.227	+1.028	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX4I1 by Parturition activity — BREAST

Explore this box plot interactively →