Sex-chromosome dosage compensation

Across TCGA patient cohorts, RNA activity of the Sex-chromosome dosage compensation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, LRBA_S2496, and EPS8L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex-chromosome dosage compensation activity versus SMC1A in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC1A →	+0.245	+0.086	<.001	.005	3	7
UCEC	LRBA_S2496 →	-0.249	-0.060	.007	.001	3	7
GBM	EPS8L2 →	-0.380	-0.038	.002	.001	3	7
LUAD	SAE1 →	+0.199	+0.047	<.001	<.001	3	6
HNSC	SMC3 →	+0.230	+0.075	.001	.008	3	6
LUAD	MSH2 →	+0.281	+0.042	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007549 vs SMC1A — HNSC

Explore this scatter interactively →