Sex-chromosome dosage compensation

Across TCGA patient cohorts, RNA activity of the Sex-chromosome dosage compensation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPF, CD248, and POLQ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex-chromosome dosage compensation activity versus CENPF in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CENPF →	+0.899	+0.505	<.001	.009	3	5
LSCC	CD248 →	-0.793	-0.228	.001	.001	3	5
LSCC	POLQ →	+0.746	+0.199	.001	.002	3	5
UCEC	NCAPH →	+0.444	+0.125	.007	.007	2	5
LSCC	CH25H →	-1.016	-0.177	.001	.006	3	4
UCEC	KIF11 →	+0.759	+0.202	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007549 vs CENPF — HNSC

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