Sex-chromosome dosage compensation

Across TCGA cell cohorts, RNA activity of the Sex-chromosome dosage compensation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELQ, LGALS3, and POLR2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex-chromosome dosage compensation activity versus HELQ in LARGE_INTESTINE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HELQ →	-0.512	-0.147	.001	.004	3	5
LIVER	LGALS3 →	+3.139	+0.192	.002	.008	3	4
OESOPHAGUS	POLR2C →	-0.689	-0.270	.001	<.001	3	4
LUNG_NSCLC_LUSC	RNF19B →	-1.212	-0.229	.001	.001	3	4
BLOOD_Leukemia	TTC8 →	-0.725	-0.094	.004	.009	3	4
UPPER_AERODIGESTIVE_TRACT	UNC119B →	-0.967	-0.185	.005	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007549 vs HELQ — LARGE_INTESTINE

Explore this scatter interactively →