Sex differentiation

Across TCGA patient cohorts, RNA activity of the Sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTBP2, KCTD8, and TSPAN13, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex differentiation activity versus PTBP2 in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTBP2 →	+0.382	+0.671	.001	.003	3	2
COAD	KCTD8 →	+0.106	+0.671	<.001	<.001	3	2
OV	TSPAN13 →	-1.121	-0.180	.009	.008	3	1
OV	CCL2 →	+1.123	+0.185	.006	.004	3	1
OV	DTX4 →	-0.987	-0.195	.002	.002	3	1
OV	POLR1E →	-0.718	-0.195	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007548 vs PTBP2 — COAD

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