Sex differentiation

Across TCGA cell cohorts, RNA activity of the Sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIC, DDIT3, and SARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex differentiation activity versus PPIC in LUNG_SCLC (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPIC →	-2.535	-0.202	.006	.007	3	6
BLOOD_Myeloma	DDIT3 →	+1.913	+0.206	.002	<.001	3	5
BLOOD_Myeloma	SARS1 →	+1.715	+0.212	.008	.003	3	5
OVARY	YBEY →	+0.889	+0.254	.003	.002	3	5
BREAST	CRIP1 →	-5.159	-0.228	<.001	<.001	3	5
BREAST	PHGDH →	+1.649	+0.200	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007548 vs PPIC — LUNG_SCLC

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