Sex determination

Across TCGA patient cohorts, RNA activity of the Sex determination pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2, NEXN_S365, and IKZF1_S63, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex determination activity versus ANK2 in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANK2 →	-0.418	-0.069	<.001	<.001	3	7
COAD	NEXN_S365 →	-0.434	-0.036	.005	.003	3	7
LSCC	IKZF1_S63 →	-0.488	-0.077	.005	<.001	3	6
LSCC	ANK2_S890 →	-0.711	-0.065	<.001	.002	3	6
HNSC	KCTD12 →	-0.367	-0.101	<.001	<.001	3	6
HNSC	LRCH3 →	-0.181	-0.065	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007530 vs ANK2 — HNSC

Explore this scatter interactively →