Sex determination

Across TCGA patient cohorts, RNA activity of the Sex determination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAIAP2L2, CERS6-AS1, and CLLU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sex determination activity versus BAIAP2L2 in GBM (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BAIAP2L2 →	-0.440	-0.660	<.001	<.001	3	4
LSCC	CERS6-AS1 →	+0.123	+0.338	.001	.005	3	3
LSCC	CLLU1 →	-0.046	-0.264	.008	.006	3	3
GBM	SUN2 →	-0.594	-0.844	<.001	<.001	3	3
GBM	OCA2 →	-0.380	-0.542	<.001	<.001	3	3
HNSC	CHI3L1 →	-0.783	-0.607	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007530 vs BAIAP2L2 — GBM

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