Sex determination

Across TCGA cell cohorts, RNA activity of the Sex determination pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR, ACSF2, and EREG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFLAR grouped by Sex determination-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CFLAR →	+1.548	+0.922	<.001	.003	3	5
SKIN	ACSF2 →	-1.222	-1.075	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	EREG →	+2.483	+1.088	.009	.006	3	4
CNS	ANKRD33B →	-1.305	-0.837	.009	.006	3	4
LUNG_NSCLC_LUAD	ATP9B →	+0.896	+0.721	.001	.001	3	4
BLOOD_Leukemia	RALGPS1 →	-0.992	-1.589	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFLAR by Sex determination activity — OESOPHAGUS

Explore this box plot interactively →