Sex determination

Across TCGA cell cohorts, RNA activity of the Sex determination pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF10, ILK, and FEZ2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF10 grouped by Sex determination-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KLF10 →	+0.219	+0.118	.009	.004	3	3
PANCREAS	ILK →	+0.227	+0.098	.003	.003	3	3
PANCREAS	FEZ2 →	-0.391	-0.224	.004	.001	3	3
PANCREAS	CLASP1 →	+0.229	+0.150	.001	<.001	3	3
BONE	CIR1 →	+0.544	+0.173	.002	.005	3	3
BONE	TMEM177 →	+0.221	+0.127	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF10 by Sex determination activity — PANCREAS

Explore this box plot interactively →