Neuromuscular junction development

Across TCGA patient cohorts, RNA activity of the Neuromuscular junction development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, CRYM, and SPATA6L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular junction development activity versus NUF2 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	-1.097	-0.779	<.001	<.001	3	4
GBM	CRYM →	+1.549	+1.372	<.001	<.001	3	4
CCRCC	SPATA6L →	+0.780	+0.699	<.001	<.001	3	4
LSCC	SPATA18 →	+0.520	+0.358	<.001	<.001	3	4
OV	ARHGAP20 →	+0.945	+0.925	<.001	<.001	3	3
OV	CTNND1 →	+0.446	+0.653	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007528 vs NUF2 — BRCA

Explore this scatter interactively →