Neuromuscular junction development

Across TCGA cell cohorts, RNA activity of the Neuromuscular junction development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL5B, RPS14, and UBFD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL5B grouped by Neuromuscular junction development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARL5B →	-0.788	-0.213	.001	.005	3	5
OVARY	RPS14 →	+0.696	+0.710	<.001	.009	3	4
SKIN	UBFD1 →	-0.438	-0.273	.009	.004	3	4
BLOOD_Lymphoma	FBXO21 →	-0.568	-0.301	.005	.001	3	4
LUNG_SCLC	EPB41L2 →	+4.295	+0.241	<.001	.001	3	4
LUNG_SCLC	KLHL5 →	+2.688	+0.263	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL5B by Neuromuscular junction development activity — STOMACH

Explore this box plot interactively →