Myoblast fusion

Across TCGA patient cohorts, RNA activity of the Myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF8, MS4A6A, and GPR65, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fusion activity versus TNFSF8 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNFSF8 →	+0.739	+0.868	.005	.001	3	7
LSCC	MS4A6A →	+0.868	+0.718	<.001	<.001	3	7
HNSC	GPR65 →	+0.651	+0.521	.001	<.001	3	7
LSCC	SLA →	+0.694	+0.539	<.001	<.001	3	7
LSCC	DPEP2 →	+0.564	+0.521	<.001	<.001	3	7
HNSC	SIRPB2 →	+0.649	+0.500	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007520 vs TNFSF8 — OV

Explore this scatter interactively →