Myoblast fusion

Across TCGA cell cohorts, RNA activity of the Myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, NUDT16L1, and ARHGAP31, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast fusion activity versus MARS2 in LUNG_NSCLC_LUSC (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MARS2 →	-1.632	-0.526	.001	.003	3	6
LUNG_NSCLC_LUSC	NUDT16L1 →	-0.941	-0.353	.002	.003	3	5
OVARY	ARHGAP31 →	+1.013	+0.155	.003	<.001	3	4
LIVER	PHTF1 →	+1.150	+0.466	.001	<.001	3	4
SKIN	GPBP1L1 →	+0.467	+0.166	.001	.008	3	4
SKIN	C1orf52 →	+0.341	+0.165	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007520 vs MARS2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →