Mesoderm development

Across TCGA patient cohorts, RNA activity of the Mesoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, PRKG1, and ILK, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm development activity versus RSU1 in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.497	+0.034	<.001	<.001	3	9
CCRCC	PRKG1 →	+0.653	+0.033	<.001	<.001	3	9
OV	ILK →	+0.347	+0.035	.004	.001	3	9
UCEC	FMNL3 →	+0.345	+0.043	.008	.004	3	8
BRCA	TIMP2 →	+0.739	+0.027	<.001	<.001	3	8
OV	MMP2 →	+0.790	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007498 vs RSU1 — BRCA

Explore this scatter interactively →