Mesoderm development

Across TCGA cell cohorts, RNA activity of the Mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROCC, ZNF644, and MUTYH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CROCC grouped by Mesoderm development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CROCC →	+0.956	+0.949	.004	.008	3	4
CNS	ZNF644 →	+0.475	+0.617	.003	.004	2	5
LUNG_SCLC	MUTYH →	+0.906	+0.297	<.001	<.001	3	4
OESOPHAGUS	ZKSCAN8 →	+1.458	+0.324	.001	<.001	3	4
LUNG_SCLC	ATAD2B →	+0.751	+0.234	.003	.002	2	5
BREAST	TFDP2 →	+0.656	+0.232	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CROCC by Mesoderm development activity — KIDNEY

Explore this box plot interactively →