Midgut development

Across TCGA patient cohorts, RNA activity of the Midgut development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, FHDC1, and TCEAL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midgut development activity versus TUBB in UCEC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB →	-0.690	-0.187	<.001	.003	3	5
OV	FHDC1 →	-0.620	-0.496	.007	.002	3	4
UCEC	TCEAL7 →	+1.293	+0.193	<.001	<.001	3	4
PDAC	CPS1 →	+1.155	+0.149	.001	.005	3	4
BRCA	ADGRB3 →	+0.217	+0.542	.005	.003	3	4
GBM	RPS18 →	-0.279	-0.618	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007494 vs TUBB — UCEC

Explore this scatter interactively →