Midgut development

Across TCGA cell cohorts, RNA activity of the Midgut development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTPS2, PLEKHG3, and MVK, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTPS2 grouped by Midgut development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CTPS2 →	+1.266	+0.432	.002	.008	3	3
LUNG_SCLC	PLEKHG3 →	-1.167	-1.075	.009	.005	3	3
UPPER_AERODIGESTIVE_TRACT	MVK →	-1.213	-0.483	.004	<.001	3	3
KIDNEY	OCM →	-0.124	-0.893	.004	<.001	3	3
STOMACH	METTL4 →	+0.705	+0.940	<.001	.007	3	3
BLOOD_Myeloma	C2orf76 →	+1.007	+1.646	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTPS2 by Midgut development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →