Midgut development

Across TCGA cell cohorts, RNA activity of the Midgut development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A9, NAT9, and ZNF789, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midgut development activity versus SLC12A9 in BLOOD_Leukemia (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC12A9 →	+1.438	+1.215	<.001	.008	3	5
BLOOD_Leukemia	NAT9 →	-0.728	-1.017	.001	.004	3	3
STOMACH	ZNF789 →	+1.103	+0.347	<.001	.001	3	3
BLOOD_Lymphoma	ZNF681 →	+1.963	+0.331	.002	.008	3	2
BLOOD_Leukemia	AURKC →	-0.831	-0.996	.001	.008	3	2
BLOOD_Leukemia	OPTN →	-2.216	-0.766	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007494 vs SLC12A9 — BLOOD_Leukemia

Explore this scatter interactively →