Endoderm development

Across TCGA patient cohorts, RNA activity of the Endoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A1, FKBP7, and THBS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoderm development activity versus COL5A1 in GBM (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL5A1 →	+1.158	+0.093	<.001	<.001	3	9
LSCC	FKBP7 →	+0.467	+0.040	<.001	.001	3	9
OV	THBS2 →	+1.522	+0.081	<.001	<.001	3	9
GBM	C1S →	+0.612	+0.065	<.001	<.001	3	9
OV	TIMP2 →	+0.728	+0.098	<.001	<.001	3	9
UCEC	SORBS3 →	+0.635	+0.066	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007492 vs COL5A1 — GBM

Explore this scatter interactively →