Endoderm development

Across TCGA patient cohorts, RNA activity of the Endoderm development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, NEMP1, and HMGA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoderm development activity versus HELLS in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HELLS →	+0.689	+0.140	.001	.001	3	7
HNSC	NEMP1 →	+0.611	+0.121	<.001	.002	3	7
LSCC	HMGA2 →	+0.973	+0.209	<.001	<.001	3	6
GBM	CCNB2 →	+0.661	+0.163	.001	.004	3	6
LSCC	E2F7 →	+0.947	+0.248	<.001	<.001	3	6
COAD	MCM10 →	+0.415	+0.183	.005	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007492 vs HELLS — HNSC

Explore this scatter interactively →