Endoderm development

Across TCGA patient cohorts, RNA activity of the Endoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIN3B_S740, SRRM2_S1483, and TOP2B_S1340, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoderm development activity versus SIN3B_S740 in HNSC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIN3B_S740 →	+0.363	+0.151	<.001	<.001	3	5
GBM	SRRM2_S1483 →	+0.417	+0.164	<.001	<.001	3	5
LSCC	TOP2B_S1340 →	+1.769	+0.362	<.001	<.001	3	5
LSCC	AFF4_S212 →	+0.562	+0.259	<.001	<.001	3	5
PDAC	HMGA2 →	+1.111	+0.192	<.001	<.001	3	5
GBM	ILF3_S62 →	+0.316	+0.185	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007492 vs SIN3B_S740 — HNSC

Explore this scatter interactively →