Endoderm development

Across TCGA cell cohorts, RNA activity of the Endoderm development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF31, PLEKHH2, and SDR39U1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF31 grouped by Endoderm development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RNF31 →	-1.434	-0.216	<.001	<.001	3	6
URINARY_TRACT	PLEKHH2 →	-1.711	-0.349	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	SDR39U1 →	-1.232	-0.217	.001	<.001	3	5
BREAST	ZACN →	-1.106	-0.233	<.001	.002	3	5
OVARY	NPIPA7 →	-0.677	-0.149	.007	.007	3	5
SOFT_TISSUE	DNMT3A →	-1.701	-0.273	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF31 by Endoderm development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →