Endoderm development

Across TCGA cell cohorts, RNA activity of the Endoderm development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP73, TLN1, and FRAT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP73 grouped by Endoderm development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TP73 →	+0.203	+0.106	.002	.007	2	7
STOMACH	TLN1 →	+0.398	+0.102	.002	.009	3	6
LUNG_SCLC	FRAT1 →	-0.290	-0.163	.001	.001	3	6
OESOPHAGUS	CAV3 →	-0.200	-0.123	.001	<.001	3	5
LUNG_SCLC	OMD →	-0.352	-0.195	<.001	<.001	3	5
LUNG_SCLC	LGR6 →	-0.258	-0.160	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP73 by Endoderm development activity — BREAST

Explore this box plot interactively →