Foregut morphogenesis

pathway activity — cross-omics
GO:0007440Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Foregut morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFI35, CENPV, and CALR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCIFI35 →-0.394-0.077<.001<.00137
LSCCCENPV →+0.690+0.091<.001<.00136
BRCACALR →-0.418-0.044<.001<.00136
LSCCMIA3_S727 →-0.493-0.070.001.00136
CCRCCTRPM2_S38 →-0.756-0.078.003.00136
CCRCCDOK3 →-0.345-0.073<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration