Foregut morphogenesis

pathway activity — cross-omics
GO:0007440Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Foregut morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD10, TTC26, and POC1B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCARD10 →+0.873+0.152<.001.00134
UCECTTC26 →+0.560+0.159<.001<.00134
UCECPOC1B-AS1 →+0.768+0.216.004<.00134
BRCASCCPDH →+0.649+0.178.003.00134
HNSCOR7E91P →+0.357+0.191.003<.00134
CCRCCRPL9P21 →-0.321-0.125<.001.00634
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration