Salivary gland development

Across TCGA patient cohorts, RNA activity of the Salivary gland development pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3B, EGFR, and SKI, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Salivary gland development activity versus FNDC3B in THYM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FNDC3B →	+1.540	+0.061	<.001	<.001	3	29
THYM	EGFR →	+1.869	+0.074	<.001	<.001	3	28
THYM	SKI →	+1.436	+0.066	<.001	<.001	3	28
SCLC	MYH9 →	+1.198	+0.086	<.001	<.001	3	27
THYM	CTDSP2 →	+0.888	+0.083	<.001	<.001	3	27
TGCT	BTBD19 →	+1.235	+0.061	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007431 vs FNDC3B — THYM

Explore this scatter interactively →