Salivary gland development

Across TCGA patient cohorts, RNA activity of the Salivary gland development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TVP23CP1, CRISPLD2, and PRKD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Salivary gland development activity versus TVP23CP1 in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TVP23CP1 →	+0.847	+0.194	.007	.001	3	5
BRCA	CRISPLD2 →	+0.610	+0.265	.002	<.001	3	5
BRCA	PRKD1 →	+0.515	+0.303	<.001	<.001	3	5
HNSC	CDK14 →	+0.580	+0.201	.002	<.001	3	5
BRCA	WSB1 →	+0.562	+0.315	.003	.004	3	4
BRCA	SSPN →	+0.689	+0.287	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007431 vs TVP23CP1 — HNSC

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