Salivary gland development

Across TCGA cell cohorts, RNA activity of the Salivary gland development pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDEM2, CBX5, and NME3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDEM2 grouped by Salivary gland development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EDEM2 →	-0.476	-1.961	.006	<.001	3	1
CNS	CBX5 →	-0.221	-1.306	.006	.002	3	1
CNS	NME3 →	+0.205	+1.306	<.001	.002	3	1
CNS	JAK3 →	+0.383	+1.961	.002	<.001	3	1
CNS	BHLHE23 →	+0.254	+1.457	.003	.009	3	1
CNS	CST8 →	-0.369	-1.847	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDEM2 by Salivary gland development activity — CNS

Explore this box plot interactively →