Salivary gland development

Across TCGA cell cohorts, RNA activity of the Salivary gland development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLGN4Y, GIN1, and TMSB4Y, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Salivary gland development activity versus NLGN4Y in CNS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NLGN4Y →	-1.915	-1.089	.008	.008	3	2
KIDNEY	GIN1 →	-0.702	-1.598	.004	<.001	3	1
KIDNEY	TMSB4Y →	-1.165	-1.634	.008	<.001	2	2
KIDNEY	C21orf58 →	-1.986	-1.723	.003	<.001	3	1
KIDNEY	SNX7 →	-0.672	-1.598	<.001	<.001	3	1
KIDNEY	SLC25A6 →	-1.373	-1.723	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007431 vs NLGN4Y — CNS

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