Peripheral nervous system development

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP3P20, PLAU, and FGFBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system development activity versus BNIP3P20 in LUAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BNIP3P20 →	-0.266	-0.270	.006	.004	3	4
HNSC	PLAU →	+0.940	+0.122	.001	.003	3	4
UCEC	FGFBP1 →	+1.060	+0.564	.002	.001	3	4
HNSC	ULBP2 →	+0.986	+0.197	.001	<.001	3	4
LUAD	ABCA12 →	+0.703	+0.272	.003	<.001	3	3
LUAD	TMEM266 →	-0.274	-0.299	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007422 vs BNIP3P20 — LUAD

Explore this scatter interactively →