Peripheral nervous system development

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDELR1, FOLH1, and FAM110C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDELR1 grouped by Peripheral nervous system development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KDELR1 →	+0.481	+0.174	.004	.008	3	3
BREAST	FOLH1 →	+1.074	+0.338	.007	.004	3	3
LUNG_SCLC	FAM110C →	+0.751	+0.226	.006	.002	3	3
LIVER	CDC42BPG →	+1.778	+0.347	<.001	.004	3	3
LIVER	S100A14 →	+4.523	+0.339	.004	.004	3	3
SOFT_TISSUE	NDUFA6 →	+0.648	+0.860	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDELR1 by Peripheral nervous system development activity — BREAST

Explore this box plot interactively →