Peripheral nervous system development

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK, BMP1, and SKI, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system development activity versus AHNAK in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AHNAK →	+2.158	+0.117	<.001	<.001	3	13
OVARY	BMP1 →	+1.388	+0.100	<.001	<.001	2	12
BLOOD_Lymphoma	SKI →	+1.000	+0.045	<.001	.009	3	11
UPPER_AERODIGESTIVE_TRACT	LUZP1 →	+0.681	+0.046	.002	.006	3	11
KIDNEY	DGCR2 →	+1.191	+0.086	<.001	.005	3	11
OESOPHAGUS	MED15 →	+1.693	+0.133	.009	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007422 vs AHNAK — BONE

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