Peripheral nervous system development

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDK, AMBP, and SEMA4F, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system development activity versus MDK in BLOOD_Lymphoma (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MDK →	-2.218	-0.164	.002	.009	2	6
BREAST	AMBP →	+2.320	+0.249	.007	<.001	3	5
KIDNEY	SEMA4F →	-1.216	-0.292	.001	<.001	3	5
KIDNEY	EFEMP2 →	-3.282	-0.269	<.001	<.001	3	4
SKIN	APOC1 →	-2.367	-0.231	.009	.002	3	4
CNS	SLC7A11 →	+1.413	+0.181	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007422 vs MDK — BLOOD_Lymphoma

Explore this scatter interactively →