Ventral midline development

Across TCGA patient cohorts, RNA activity of the Ventral midline development pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, C19orf44, and CDK20, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventral midline development activity versus SMO in ESCA (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	SMO →	+1.645	+0.102	<.001	<.001	3	25
LGG	C19orf44 →	+0.523	+0.041	<.001	<.001	3	24
THYM	CDK20 →	+1.047	+0.081	<.001	<.001	3	24
KICH	ZNF500 →	+0.508	+0.060	<.001	.001	3	23
ESCA	GLI2 →	+2.068	+0.118	<.001	<.001	3	23
SARC	GLI1 →	+1.899	+0.068	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007418 vs SMO — ESCA

Explore this scatter interactively →